HORDB

ID: hor005711
Uniprot ID: P28672
Protein name: Neuropeptide Y
Gene name: npy
Organism: Carassius auratus (Goldfish)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: YPTKPDNPGEGAPAEELAKYYSALRHYINLITRQRY
Length: 36
Propeptide: MHPNMKMWTGWAACAFLLFVCLGTLTEGYPTKPDNPGEGAPAEELAKYYSALRHYINLITRQRYGKRSSADTLISDLLIGETESHPQTRYEDQLVW
Signal peptide: MHPNMKMWTGWAACAFLLFVCLGTLTEG
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005711_AF2.pdb

hor005711_ESM.pdb

Mass:	482115	Formula:	C190H288N52O56
Absent amino acids:	CFMVW	Common amino acids:	Y
pI:	8.91	Basic residues:	6
Polar residues:	12	Hydrophobic residues:	9
Hydrophobicity:	-103.61	Boman Index:	-8401
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	65.28
Instability Index:	5305.28	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86